| Sewer Rat | 23 | | No | Pierce | -4% Blunt 10% Cut |
| Squalid Ghost | 23 | | No | Pierce | 20% Nature 20% Soul 20% Mind -20% Body 75% Poison 75% Disease |
| Swamp Slug | 27 | | No | | -10% Pierce 25% Disease |
| Small Crab | 28 | Sea Creature | No | Cut | 20% Pierce 50% Arrow -20% Soul 10% Mind |
| Spectral Orc Forager | 29 | | No | | |
| Skeleton Wolf | 32 | | No | | -25% Blunt 25% Pierce 25% Cut 25% Arrow 25% Soul 100% Poison 100% Disease |
| Spectral Orc Footman | 35 | | No | | |
| Spectral Orc Foreman | 44 | | No | | |
| Skeleton Pirate | 48 | | No | Cut | -4% Blunt 20% Pierce 20% Mind -10% Body |
| Spectral Orc Warrior | 49 | | No | | |
| Spectral Pet | 50 | | No | | 25% Nature 25% Soul 25% Mind 25% Body |
| Sea Turtle | 52 | | No | | |
| Sand Spider | 55 | | No | | 25% Arrow 25% Nature 100% Poison |
| Spectral Horned Berserker | 58 | | No | | |
| Spectral Orc Wizard | 59 | | No | | |
| Squid | 60 | | No | | |
| Shadow Spider | 62 | | No | | 100% Poison |
| Sickly Troll | 65 | Giant | No | | |
| Sand Sting | 65 | | Yes | | -10% Blunt 50% Arrow 15% Nature 100% Poison |
| Sea Bandit | 67 | Humanoid | No | Cut | 20% Blunt 15% Pierce -20% Body |