| Spectral General | 73 | | No | | 25% Cut 25% Body 25% Poison 25% Disease |
| Spectral Dragon of Roachard | 94 | | Yes | Pierce | 100% Blunt 100% Pierce 100% Cut 50% Arrow 50% Poison 50% Disease |
| Spectral Destroyer | 78 | | No | | |
| Spectral Demon Overlord | 90 | | No | | |
| Sonic Flyer | 6 | Vermin | No | Pierce | 25% Nature 25% Poison |
| Son of Scalo | 145 | | Yes | Cut | 20% Pierce 20% Nature 25% Body 100% Poison |
| So Kang Kang | 200 | Animal | Yes | Blunt | 50% Blunt -5% Cut 75% Mind 50% Body |
| Snow Terror | 82 | Demon | No | | -10% Arrow 10% Magic Missile 5% Nature 5% Mind |
| Snake | 2 | Vermin | No | Pierce | 75% Poison |
| Snagglefang | 100 | | No | | |
| Small Skeleton | 5 | | No | Blunt | -25% Blunt 5% Pierce 5% Cut 25% Arrow |
| Small Grizzly Bear | 8 | | No | Cut | |
| Small Crab | 28 | Sea Creature | No | Cut | 20% Pierce 50% Arrow -20% Soul 10% Mind |
| Slobberknocker | 87 | | No | | |
| Slimy Ooze | 4 | | No | Body | -10% Blunt 3% Body |
| Skeleton Wolf | 32 | | No | | -25% Blunt 25% Pierce 25% Cut 25% Arrow 25% Soul 100% Poison 100% Disease |
| Skeleton Warrior | 17 | | No | Cut | -25% Blunt 25% Pierce 25% Cut 25% Arrow 25% Soul 100% Poison 100% Disease |
| Skeleton Pirate | 48 | | No | Cut | -4% Blunt 20% Pierce 20% Mind -10% Body |
| Skeleton | 10 | | No | Blunt | -25% Blunt 25% Pierce 25% Cut 25% Arrow 25% Soul 100% Poison 100% Disease |
| Skeletal Pup | 6 | | No | | -25% Blunt 5% Pierce 5% Cut 25% Arrow 5% Soul 100% Poison 100% Disease |