| Spectral General | 73 | | No | | 25% Cut 25% Body 25% Poison 25% Disease |
| Storm Giant | 74 | Giant | No | Cut | |
| Skeletal Fiend | 78 | | No | | -5% Soul |
| Spectral Destroyer | 78 | | No | | |
| Stone Giant | 80 | | No | Blunt | |
| Snow Terror | 82 | Demon | No | | -10% Arrow 10% Magic Missile 5% Nature 5% Mind |
| Slobberknocker | 87 | | No | | |
| Spectral Demon Overlord | 90 | | No | | |
| Shark | 90 | | No | | |
| Spectral Dragon of Roachard | 94 | | Yes | Pierce | 100% Blunt 100% Pierce 100% Cut 50% Arrow 50% Poison 50% Disease |
| Snagglefang | 100 | | No | | |
| Storm Giant Elite | 100 | Giant | No | Cut | |
| Swamp Beast | 105 | | No | Pierce | 100% Poison 100% Disease |
| Scary Spider | 105 | | No | | 25% Blunt 25% Cut -10% Nature 50% Mind 100% Poison |
| Sand Wurm | 105 | Vermin | No | Pierce | 15% Nature 15% Soul 15% Mind 15% Body |
| Silverback | 109 | | No | Blunt | 25% Blunt 10% Pierce |
| Supply Shed Guard | 110 | | No | | |
| Sand Golem | 110 | Giant | No | | 80% Blunt 50% Mind 100% Poison 100% Disease |
| Spectre of Ryonkah | 115 | | No | | 20% Arrow 66% Soul 100% Poison |
| Savanna Lion | 125 | | No | Pierce | 20% Blunt 20% Soul -4% Mind |