| Sea Turtle | 52 | | No | | |
| Skeletal Apprentice | 8 | | No | | -25% Blunt 25% Pierce 25% Cut 25% Arrow 25% Soul 100% Poison 100% Disease |
| Silverback | 109 | | No | Blunt | 25% Blunt 10% Pierce |
| Sickly Troll | 65 | Giant | No | | |
| Sheep | 2 | | No | Blunt | 50% Disease |
| Shark | 90 | | No | | |
| Shambler | 22 | Humanoid | No | | |
| Shadow Spider | 62 | | No | | 100% Poison |
| Shadow | 17 | | No | Cut | 50% Blunt 25% Pierce 25% Cut 25% Arrow 25% Nature 25% Soul 25% Mind 25% Body 25% Poison 25% Disease |
| Shade | 20 | | No | | 25% Pierce 25% Soul 25% Body 50% Disease |
| Sewer Rat | 23 | | No | Pierce | -4% Blunt 10% Cut |
| Sand Golem | 110 | Giant | No | | 80% Blunt 50% Mind 100% Poison 100% Disease |
| Sea Bandit | 67 | Humanoid | No | Cut | 20% Blunt 15% Pierce -20% Body |
| Scorpion | 5 | | No | Pierce | -10% Blunt 25% Nature 25% Soul 25% Body 100% Poison |
| Skeletal Fiend | 78 | | No | | -5% Soul |
| Scary Spider | 105 | | No | | 25% Blunt 25% Cut -10% Nature 50% Mind 100% Poison |
| Savanna Lion | 125 | | No | Pierce | 20% Blunt 20% Soul -4% Mind |
| Skeletal Mage | 12 | | No | Blunt | -25% Blunt 25% Pierce 25% Cut 25% Arrow 25% Soul 100% Poison 100% Disease |
| Sand Wurm | 105 | Vermin | No | Pierce | 15% Nature 15% Soul 15% Mind 15% Body |
| Swamp Slug | 27 | | No | | -10% Pierce 25% Disease |