| So Kang Kang | 200 | Animal | Yes | Blunt | 50% Blunt -5% Cut 75% Mind 50% Body |
| Son of Scalo | 145 | | Yes | Cut | 20% Pierce 20% Nature 25% Body 100% Poison |
| Stratus Proudblood | 135 | | Yes | | |
| Sandy Claws | 135 | | Yes | Cut | 20% Blunt 25% Pierce 50% Cut 20% Soul 20% Mind |
| Savanna Lion | 125 | | No | Pierce | 20% Blunt 20% Soul -4% Mind |
| Spectre of Ryonkah | 115 | | No | | 20% Arrow 66% Soul 100% Poison |
| Supply Shed Guard | 110 | | No | | |
| Sand Golem | 110 | Giant | No | | 80% Blunt 50% Mind 100% Poison 100% Disease |
| Silverback | 109 | | No | Blunt | 25% Blunt 10% Pierce |
| Swamp Beast | 105 | | No | Pierce | 100% Poison 100% Disease |
| Scary Spider | 105 | | No | | 25% Blunt 25% Cut -10% Nature 50% Mind 100% Poison |
| Sand Wurm | 105 | Vermin | No | Pierce | 15% Nature 15% Soul 15% Mind 15% Body |
| Storm Giant Elite | 100 | Giant | No | Cut | |
| Snagglefang | 100 | | No | | |
| Spectral Dragon of Roachard | 94 | | Yes | Pierce | 100% Blunt 100% Pierce 100% Cut 50% Arrow 50% Poison 50% Disease |
| Spectral Demon Overlord | 90 | | No | | |
| Shark | 90 | | No | | |
| Slobberknocker | 87 | | No | | |
| Snow Terror | 82 | Demon | No | | -10% Arrow 10% Magic Missile 5% Nature 5% Mind |
| Stone Giant | 80 | | No | Blunt | |