| Spider | 3 | Vermin | No | Pierce | |
| Sand Wurm | 105 | Vermin | No | Pierce | 15% Nature 15% Soul 15% Mind 15% Body |
| Snake | 2 | Vermin | No | Pierce | 75% Poison |
| Sonic Flyer | 6 | Vermin | No | Pierce | 25% Nature 25% Poison |
| Small Crab | 28 | Sea Creature | No | Cut | 20% Pierce 50% Arrow -20% Soul 10% Mind |
| Sea Bandit | 67 | Humanoid | No | Cut | 20% Blunt 15% Pierce -20% Body |
| Shambler | 22 | Humanoid | No | | |
| Sickly Troll | 65 | Giant | No | | |
| Storm Giant | 74 | Giant | No | Cut | |
| Sand Golem | 110 | Giant | No | | 80% Blunt 50% Mind 100% Poison 100% Disease |
| Storm Giant Elite | 100 | Giant | No | Cut | |
| Snow Terror | 82 | Demon | No | | -10% Arrow 10% Magic Missile 5% Nature 5% Mind |
| So Kang Kang | 200 | Animal | Yes | Blunt | 50% Blunt -5% Cut 75% Mind 50% Body |
| Sea Turtle | 52 | | No | | |
| Shadow | 17 | | No | Cut | 50% Blunt 25% Pierce 25% Cut 25% Arrow 25% Nature 25% Soul 25% Mind 25% Body 25% Poison 25% Disease |
| Shade | 20 | | No | | 25% Pierce 25% Soul 25% Body 50% Disease |
| Sewer Rat | 23 | | No | Pierce | -4% Blunt 10% Cut |
| Swamp Slug | 27 | | No | | -10% Pierce 25% Disease |
| Savanna Lion | 125 | | No | Pierce | 20% Blunt 20% Soul -4% Mind |
| Sandy Claws | 135 | | Yes | Cut | 20% Blunt 25% Pierce 50% Cut 20% Soul 20% Mind |